Aravinda’s Reflections
Learn about Dr. de Silva’s beginnings at UNC and his experiences in a constantly changing scientific environment
My wife, Amy, and I moved from New Haven to Chapel Hill in 1998 to start our first “real” jobs. I was joining the Department of Microbiology and Immunology and Amy was joining the Department of Medicine. I had interviewed at several institutions, but I knew UNC was right for us because of the highly collegial atmosphere within the Department and the genuine efforts to accommodate both me and my wife. I am especially thankful to Jeff Frelinger, the Chair of the Department, and Fred Sparling, the Chair of Medicine at the time (and a former Chair of Microbiology) who coordinated the recruitment effort and welcomed us both to Chapel Hill.
The Department was housed on 3 floors (6-8) in the Mary Ellen Jones Building. My laboratory was on the 7th floor in space previously occupied by Phil Bassford. Phil was a much-loved member of the Department, who had tragically died several years before my arrival in 1998.
I was recruited to the Department as a Bacteriologist. I had secured two career development awards from the NIH and Arthritis Foundation before arriving at Chapel Hill and I thought success in academia was all about grant funding. I soon realized that my colleagues were a lot more interested in my ideas and scientific goals and not about how much money I raised for my research. Janne Cannon was the “group leader” for Bacteriology and she encouraged me to focus on experiments instead of wasting my time submitting “half-baked” research proposals. This was very good advice.
I was inspired by several senior faculty in the Department like Clyde Hutchison, Marshall Edgell, Steve Bachenheimer, Priscilla Wyrick and Bob Johnston, who were passionate about their work. My laboratory was sandwiched between Clyde and Marshall’s laboratories. Both Clyde and Marshall are outstanding basic scientists who had made discoveries that were foundational to modern Molecular Biology. Clyde had an eclectic group of scientists working on interesting problems like the minimal genome required for life or mapping all RNA transcripts generated from a single mammalian genome. These studies were visionary because this was the era before the establishment of “omics” technologies, which we now take for granted. New ideas and experiments were the fabric of the Department.
Soon after I joined, the Department wanted to recruit someone working on “Bioinformatics” because we had a feeling this was going to be important in the future. However, we had a hard time writing the job description because no one could define Bioinformatics or the research to be done by the new recruit. We had several interesting and entertaining faculty meetings to define Bioinformatics Research. A search was initiated, and Morgan Giddings was recruited as the Department’s and, possibly, the School of Medicine’s first Bioinformatics expert.
For example, in the past our students faced an onerous qualifying exam, where they were expected to write a NIH style proposal on a topic completely unrelated to their thesis work. Student proposals were reviewed by a NIH style faculty study section. The whole process could take 9 months from the beginning to the end. I felt that the entire process stifled scientific creativity and took time away from independent research. I also felt that, as faculty, we had not adequately prepared the students for this exam. Over the years, we have had a healthy debate about the qualifying exam and modified the process to be less time consuming and more educational for the student.
In 2009, Marcia Hobbs (Professor of Microbiology & Immunology and Medicine), Bruce Alexander (Teaching Coordinator of the Department), and I took over the course. We had several meetings with Fred Sparling, Jeff Frelinger and Tom Belhorn (Department of Pediatrics) to discuss how best to shorten the course and revise the curriculum to better meet the needs of medical students. The revised course was well-received, and we continuously improved the course over the next 5 years. I am especially indebted to Marcia and Bruce who are passionate educators and I learned a lot from both of them. In 2014, the School of Medicine decided to completely restructure the curriculum and no longer assign blocks of the curriculum to Basic Science Departments. While basic science faculty, including several faculty from our Department, still teach medical students, as a Department we play a minor role in the didactic education of Medical students.